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Other Crystal-Induced Diseases

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Other crystals besides monosodium urate, calcium pyrophosphate dihydrate (CPPD), and calcium hydroxyapatite crystals can lead to soft tissue, articular, and osseous abnormalities. Cholesterol crystals are identified in patients with rheumatoid arthritis, as well as osteoarthritis; they appear to reflect local rather than systemic alterations and may be responsible for low-grade synovial inflammation. When corticosteroid preparations are injected into joints, there is a mild synovial inflammatory response. Accumulation of calcium oxalate crystals is seen in both primary and secondary oxalosis, the latter most typically occurring as a complication of chronic renal disease. Destructive lesions of the metaphyseal regions of tubular bones, discovertebral regions, and sometimes joints become apparent. Cystine, haemoglobin, and Charcot-Leyden crystals can also accumulate in bones or joints, although the precise relationship between such accumulation and structural abnormality is not known. Xanthine and hypoxanthine crystals may be deposited in muscles.

The candidate will learn the mechanics of putting together an electronic poster presentation in lecture type format.
This will be an official peer-reviewed publication.
The publication will be a favorable addition to the candidate's CV.
The candidate will be the first author, and I am the second author.
A candidate is not limited to completing one project. He/she can do as many as they like! (There are always topics to teach about)
The candidate, myself, King's College Hospital Department of Radiology and King's College all benefit from this publication.
Dennis K. Bielecki, MD
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