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Lipidoses, Histiocytoses, and Hyperlipoproteinemias

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Musculoskeletal findings are a significant part of the lipidoses, histiocytoses, and hyperlipoproteinemias. In Gaucher’s disease, cellular accumulation in the bone marrow leads to replacement of trabeculae, endosteal erosion of the cortex, cortical thinning, lytic defects, and fractures. Osteonecrosis and modelling deformities of the long bones are characteristic. The findings in Niemann-Pick disease may resemble those of Gaucher’s disease, although osteonecrosis is not encountered. This latter abnormality is detected in Fabry’s disease. Multicentric reticulohistiocytosis is characterized by the proliferation of histiocytes in various tissues. Skeletal involvement can lead to a symmetrical destructive polyarthritis with a predilection for the interphalangeal joints of the hands and feet, early and severe abnormalities of the atlantoaxial joints, and changes in other articulations of the appendicular skeleton. The Langerhans cell histiocytoses consist of three disorders: eosinophilic granuloma, Hand-Schüller-Christian disease, and Letterer-Siwe disease. Although these disorders share numerous radiographic and pathologic features, their classic clinical characteristics allow their separation into discrete entities.

The candidate will learn the mechanics of putting together an electronic poster presentation in lecture type format.
This will be an official peer-reviewed publication.
The publication will be a favorable addition to the candidate's CV.
The candidate will be the first author, and I am the second author.
A candidate is not limited to completing one project. He/she can do as many as they like! (There are always topics to teach about)
The candidate, myself, King's College Hospital Department of Radiology and King's College all benefit from this publication.
Dennis K. Bielecki, MD
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