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Brain Metastasis Research Project

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This project is part of Bristol Medical School's BAME Initiative. It is open to BAME (Black, Asian, and Minority Ethnic) students, in the hopes of overcoming the BAME attainment gap and making research far more accessible to these underrepresented groups.
Aim of the Brain Metastasis Research Project:
Discover risk factors, biomarkers of progression and drug targets for brain metastasis

Over 25,000 patients in the UK suffer a brain metastasis,
most commonly from primary sites such as lung, breast, colorectal, renal and skin (melanoma), with an overall survival of less than 20% over 5 years. We would like to research risk factors for brain metastasis in order to develop strategies to prevent them.

Step One: A systematic review will be carried out to identify previous findings regarding links between potential risk factors (e.g. smoking, alcohol, Body Mass Index, type 1 diabetes, high blood pressure, vitamin E levels, caffeine consumption etc) and brain metastasis.

Step Two: In accordance with the Genome Wide Association Studies (GWAS) available genetic instruments for the identified risk factors will be prepared.

Step Three: Using two-sample Mendelian randomization (Mendelian randomization is a method of measuring the variation of gene function to examine the effect of modifiable exposure on disease in observational studies), the team will use these genetic instruments to evaluate the identified risk factors correlation with brain metastasis.

Lead Supervisor: Dr Kathreena Kurian
BAME Initiative
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