A survey of the musculoskeletal manifestations associated with certain medications and chemical substances indicates that in some cases the therapeutic regimen may be more detrimental than the disease. A variety of teratogenic drugs can lead to significant fetal anomalies. Corticosteroids and other anti-inflammatory agents can produce osteoporosis, osteonecrosis, and neuropathic-like alterations. Osteosclerosis, periostitis, osseous excrescences, ligamentous calcification, and dental abnormalities can accompany fluorosis. Injection of dopamine and related substances may lead to gangrene, requiring amputation, whereas soft tissue calcification may appear after calcium gluconate injection or ingestion of milk and alkali. New bone formation is seen in some patients receiving prostaglandins or isotretinoin. Quinolones may produce tendinosis and tendon rupture. The candidate will learn the mechanics of putting together an electronic poster presentation in lecture type format. This will be an official peer-reviewed publication. The publication will be a favorable addition to the candidate's CV. The candidate will be the first author, and I am the second author. A candidate is not limited to completing one project. He/she can do as many as they like! (There are always topics to teach about) The candidate, myself, King's College Hospital Department of Radiology and King's College all benefit from this publication.
Dennis K. Bielecki, MD
Remarxs